Thermo Fisher Scientific KCNE1 Polyclonal Antibody
KCNE1 단백질을 표적으로 하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot에 최적화되어 있으며 인간 및 생쥐 반응성. 항원 친화 크로마토그래피로 정제된 고순도 제품으로, 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용 가능.
- 판매단위
- pk
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Thermo Fisher Scientific KCNE1 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human KCNE1 (UniProt ID: P15382-1, range 1–129) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719720 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Kcne1 is a member of voltage-gated potassium (Kv) channels, which regulate diverse physiological processes including neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
The Kcne1 gene encodes a membrane protein similar to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. It may be involved in cardiac and neurologic abnormalities found in AMME contiguous gene syndrome.
Functionally, Kcne1 acts as a potassium channel ancillary subunit essential for generating native K(+) currents by forming heteromeric complexes with Kv channel alpha subunits. It also functions as an inhibitory beta-subunit of the repolarizing cardiac potassium channel KCNQ1.
Diseases associated with KCNE1 include Jervell and Lange-Nielsen Syndrome 2 and Long QT Syndrome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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