Thermo Fisher Scientific ADAP Polyclonal Antibody
Thermo Fisher Scientific의 ADAP Polyclonal Antibody는 인간 및 마우스 시료에서 ADAP 단백질 검출용으로 최적화된 다클론 항체입니다. Western blot 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 2–8°C 보관 시 안정적입니다.
- 카탈로그번호
- PA520400
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific ADAP Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 20 amino acid peptide from near the carboxy terminus of human ADAP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155624 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-20400 can be used with blocking peptide PEP-0517
Target Information
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to integrin avidity governing T cell adhesion. TCR stimulation promotes formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through association with ADAP activates the NF-kappa-B family of transcription factors.
Further studies show ADAP controls optimal T cell proliferation, cytokine production, and expression of Bcl-x(L), indicating its role in antigen-dependent T cell activation.
At least three isoforms of ADAP are known.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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