Thermo Fisher Scientific MORF4 Polyclonal Antibody
MORF4 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 사용 가능하며, 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS 용액 내 0.02% sodium azide 포함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the amino terminus of human MORF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157883 |
Product Specific Information
- A suggested positive control is K562 cell lysate.
- PA5-20399 can be used with blocking peptide PEP-0516.
Target Information
Cellular senescence is the terminal non-dividing state that normal cells enter following completion of their proliferative potential. Fusions of immortal human cell lines with each other have led to their assignment to one of four complementation groups. Mortality factor 4 (MORF4) was identified as the lead member of a family of transcription factor-like proteins that reverses this immortal phenotype. Like other members in this family, MORF4 is localized to the nucleus and possesses transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that might allow it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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