Thermo Fisher Scientific CD104 Monoclonal Antibody (422325), APC
인간 CD104(Integrin beta 4)을 인식하는 마우스 단클론 항체로, APC 형광체로 결합되어 유세포분석(Flow Cytometry)에 적합합니다. 비특이적 교차반응이 없으며, 4°C에서 암소 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 10 µL per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 422325 |
| Immunogen | CHO-derived recombinant human Integrin beta 4/CD104 (Asn28–Ser710) |
| Conjugate | APC (Allophycocyanin) |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | Buffered saline solution with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609373 |
Product Specific Information
In Western blots, no cross-reactivity with recombinant human Integrin beta 1, beta 2, beta 3, beta 5, beta 6, beta 8, or recombinant mouse Integrin beta 4 is observed.
Target Information
Integrins are heterodimers composed of alpha and beta subunits that form noncovalently associated transmembrane glycoprotein receptors. Different alpha–beta combinations determine ligand-binding specificity. Integrins mediate cell–matrix and cell–cell adhesion, transmitting signals that regulate gene expression and cell growth.
The Integrin beta 4 (CD104) subunit acts as a receptor for laminins and typically associates with the alpha 6 subunit. It plays a key role in invasive carcinoma biology. Mutations in this gene are linked to epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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