Thermo Fisher Scientific Phospho-PDGFRB (Tyr740) Polyclonal Antibody
PDGFRB 단백질의 Tyr740 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 IHC에 적합하며 인간, 마우스, 랫트 시료에서 반응. 고순도 정제 및 안정적 액상 형태로 제공.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-PDGFRB (Tyr740) Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PDGFRB (Accession P09619), corresponding to amino acid residues around phosphorylated Tyr740 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816251 |
Product Specific Information
Antibody detects endogenous levels of PDGF Receptor beta only when phosphorylated at Tyrosine 740.
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The identity of the bound growth factor determines whether the receptor forms a homodimer or heterodimer with PDGFR alpha or beta polypeptides.
The PDGFRB gene is located on chromosome 5, flanked by genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor. A translocation between chromosomes 5 and 12 that fuses PDGFRB (CD140b) with the ETV6 leukemia gene results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.