Thermo Fisher Scientific FMO1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FMO1. Recombinant protein control fragment (Product #RP-93980). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FMO1,uniProtId:Q01740-1,ncbiNodeId:9606,antigenRange:247-348,antigenLength:532,antigenImageFileName:PA5-54865_FMO1_Q01740-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54865_FMO1_Q01740-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641684

Product Specific Information

Immunogen sequence: LPTPIVTWLM ERKINNWLNH ANYGLIPEDR TQLKEFVLND ELPGRIITGK VFIRPSIKEV KENSVIFNNT SKEEPIDIIV FATGYTFAFP FLDESVVKVE DG

Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 80%.

Target Information

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.