Thermo Fisher Scientific FMO1 Polyclonal Antibody
Human FMO1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:200~1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보존. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FMO1. Recombinant protein control fragment (Product # RP-93980) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2641684 |
Product Specific Information
Immunogen sequence:
LPTPIVTWLM ERKINNWLNH ANYGLIPEDR TQLKEFVLND ELPGRIITGK VFIRPSIKEV KENSVIFNNT SKEEPIDIIV FATGYTFAFP FLDESVVKVE DG
Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 80%
Target Information
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans, resulting in a subpopulation with reduced TMA N-oxidation capacity (trimethylaminuria, or fish odor syndrome).
Three forms of the enzyme are encoded by genes clustered in the 1q23–q25 region:
- FMO1: Found in fetal liver
- FMO2: Found in adult liver
- FMO3: Expressed in various tissues
Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyze the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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