Thermo Fisher Scientific CFLAR Monoclonal Antibody (OTI1B1), TrueMAB
CFLAR 단백질을 표적으로 하는 Mouse IgG2b 단일클론 항체로, Western blot에 최적화됨. Human 종에 반응하며, Lyophilized 형태로 제공. 세포사멸 경로 연구용으로 적합하며, 재구성 및 결합 실험에 용이.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–272 of human CFLAR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
FLIP (CFLAR) is an apoptosis regulator protein that serves as a key link between cell survival and cell death pathways in mammalian cells.
It inhibits TNFRSF6-mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC), blocking further recruitment and processing of caspase-8.
Full-length and shorter isoforms can either induce or inhibit TNFRSF-triggered apoptosis.
Lacks enzymatic (caspase) activity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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