Thermo Fisher Scientific GSTM1 Monoclonal Antibody (1H4A4)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-31757 has been tested in indirect ELISA.

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the mu class, which functions in detoxification of electrophilic compounds—including carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products—by conjugation with glutathione.
The mu class genes are clustered on chromosome 1p13.3 and are highly polymorphic, affecting susceptibility to carcinogens and drug efficacy. Null mutations in this gene class are linked to increased cancer risk due to heightened vulnerability to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.