Thermo Fisher Scientific CD95/FAS/TNFRSF6 Recombinant Rabbit Monoclonal Antibody (FAS/9322R)

Applications

Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: MCF-7 cells (IF/FACS), human hepatocellular or bladder carcinoma (IHC)
• Cellular Location: Cell surface

Target Information

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor of the TNFR superfamily. It also exists in a soluble form (~26 kDa). Stimulation of FAS leads to aggregation of FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases, resulting in apoptosis.
FAS can activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and participates in proliferative signaling in fibroblasts and T cells. Multiple spliced variants exist, with some lacking the transmembrane domain that may negatively regulate apoptosis.
The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses via apoptosis induction.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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