Thermo Fisher Scientific SLC25A13 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2, or CTLN2, is a 675 amino acid multi-pass mitochondrial inner membrane protein. It is expressed in liver, pancreas, kidney, brain, heart, and placenta. Citrin functions as a calcium-dependent glutamate and aspartate carrier involved in the urea cycle.
It belongs to the mitochondrial carrier family, containing three Solcar repeats and four EF-hand domains for calcium binding.
Mutations in the SLC25A13 gene cause citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD).
CTLN2 is an autosomal recessive urea cycle disorder characterized by neuropsychiatric symptoms such as memory loss, seizures, and coma. NICCD manifests in infancy with low birth weight, reduced bile flow, growth retardation, and hepatic fibrosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.