Thermo Fisher Scientific SLC25A13 Polyclonal Antibody
SLC25A13 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot과 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관. 인간, 마우스, 랫트 반응성.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human SLC25A13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720565 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2, or CTLN2, is a 675 amino acid multi-pass mitochondrial inner membrane protein. It is expressed in liver, pancreas, kidney, brain, heart, and placenta. Citrin functions as a calcium-dependent glutamate and aspartate carrier involved in the urea cycle.
It belongs to the mitochondrial carrier family, containing three Solcar repeats and four EF-hand domains for calcium binding.
Mutations in the SLC25A13 gene cause citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD).
CTLN2 is an autosomal recessive urea cycle disorder characterized by neuropsychiatric symptoms such as memory loss, seizures, and coma. NICCD manifests in infancy with low birth weight, reduced bile flow, growth retardation, and hepatic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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