Thermo Fisher Scientific Phospho-SMC1 (Ser966) Polyclonal Antibody
Phospho-SMC1 (Ser966) 폴리클로날 항체로, 인간 SMC1의 Ser966 인산화 부위를 인식합니다. Western blot과 IHC(P)에서 검증되었습니다. Rabbit IgG 기반의 비결합 액상 항체이며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human SMC1 around the phosphorylation site of Ser966 (S-G-SP-Q-R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554932 |
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair, and global transcriptional repression. These proteins are conserved in eukaryotes and are essential for proper mitotic chromosome segregation. The SMC1 and SMC3 proteins form a heterodimeric complex required for metaphase progression in mitotic cells, specifically responsible for sister chromatid cohesion during metaphase. Mutations in the SMC1 gene can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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