Thermo Fisher Scientific BIN1 Monoclonal Antibody (99D)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

BIN1 antibody is specific for human BIN1 protein. BLAST analysis suggests cross-reactivity with BIN1 from human and mouse sources (100% homology with the immunizing sequence). Cross-reactivity with BIN1 from other species has not been determined.

Target Information

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with tumor suppressor features. Isoforms expressed in the central nervous system may be involved in synaptic vesicle endocytosis and interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms expressed in muscle and ubiquitously expressed variants localize to the cytoplasm and nucleus, activating a caspase-independent apoptotic process. Mouse studies indicate an important role in cardiac muscle development. Alternative splicing results in ten transcript variants encoding different isoforms, and aberrant splice variants have been described in tumor cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.