Thermo Fisher Scientific Dematin Polyclonal Antibody
Dematin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간 및 생쥐 반응성. 액상 형태, 1 mg/mL 농도, Affinity chromatography로 정제. 세포골격 안정화 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DMTN (Accession Q08495), corresponding to amino acid residues S377–F405 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818400 |
Product Specific Information
Antibody detects endogenous levels of total Dematin.
Target Information
The protein encoded by this gene is an actin-binding and bundling protein that plays a structural role in erythrocytes by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner.
This protein contains a core domain in the N-terminus and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, it exists as a trimer composed of two 48 kDa polypeptides and one 52 kDa polypeptide.
Different subunits arise from alternative splicing in the 3′ coding region, where the headpiece domain is located.
Disruption of this gene has been correlated with autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression.
Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 정보: PA5-99467_Dematin_Q08495-1_Rabbit.svg, PA5-99467_Dematin_Q08495-1_Rabbit_PDP.jpeg)
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