Thermo Fisher Scientific PDGF-D Polyclonal Antibody
PDGF-D 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 IHC에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, 0.25 mg/mL 농도의 액상 형태로 제공.
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- 402100
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 3 publications |
| Immunohistochemistry (IHC) | – | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of the human PDGF-D |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533455 |
Target Information
The platelet-derived growth factor (PDGF) family consists of four members: PDGF-A, PDGF-B, PDGF-C, and PDGF-D. These form disulphide-bonded dimeric isoforms that are essential for growth, survival, and function in various connective tissue cells. Their signaling occurs via tyrosine kinase receptors PDGFR-α and PDGFR-β and is critical for organ development.
PDGF-D, similar to PDGF-C, is secreted as a disulphide-linked homodimer (PDGF-DD). It induces cellular transformation and promotes tumor growth by enhancing proliferation and neovascularization. PDGF-D is implicated in brain tumor development and may influence prostate cancer progression. Expression is found in fibroblastic adventitial cells, cultured endothelial cells, and various tumor cell lines (ovarian, renal, lung, astrocytoma, medulloblastoma) as well as human kidney tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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