Thermo Fisher Scientific TMP21 Polyclonal Antibody
Rabbit polyclonal antibody against human TMP21, validated for WB and IHC. Recognizes conserved regions across multiple species. Suitable for studying vesicular transport and γ-secretase regulation. Supplied as liquid, 0.9 mg/mL, stored at -20°C.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Chicken, Human, Mouse, Non-human primate, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic internal peptide corresponding to residues 100–200 of the human TMP21 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 30% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2204347 |
Product Specific Information
This sequence is 100% conserved within monkey, mouse, hamster, rat, rabbit, and bovine TMP21.
Suggested positive control: human liver protein.
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates the γ-secretase, but not the ε-secretase, cleavage activity of the amyloid precursor protein.
The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave the amyloid precursor protein at γ- and ε-sites, leading to the accumulation of the Aβ cleavage product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments indicate TMP21 may play a regulatory role in this complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Aβ production, demonstrating that TMP21 modulates γ-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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