Thermo Fisher Scientific CD3e (T-Cell Marker) Recombinant Rabbit Monoclonal Antibody (C3e/3171R)
CD3e(T-Cell Marker)을 인식하는 재조합 토끼 단클론 항체로, 인간 시료에 반응하며 IHC 및 ELISA에 적합. 고순도 Protein A/G 정제, PBS 용액 형태로 제공. -20°C에서 보관하며 개·고양이에는 반응하지 않음.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | 2–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | C3e/3171R |
| Immunogen | Recombinant human CD3e fragment (around aa 23–119) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Dog or Cat
Target Information
The CD3 subunit complex is crucial for transducing antigen-recognition signals into the cytoplasm of T cells and regulating the surface expression of the TCR complex.
T cell activation through the TCR involves CD3 gamma, delta, epsilon, and zeta subunits, which belong to the immunoglobulin superfamily encoded on human chromosome 11.
CD3 may play a role in TCR-induced growth arrest, cell survival, and proliferation.
The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Defects in the CD3 gene are associated with CD3 immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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