Thermo Fisher Scientific SH2D1A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Immunogen Information

• Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 3–29)
• Recombinant protein control fragment: Product #RP-110143
• Immunogen sequence: AVAVYHGKIS RETGEKLLLA TGLDGSY
• Antigen sequence identity: Mouse 96%; Rat 93%

Target Information

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. The protein contains an SH2 domain and a short tail, and associates with the signaling lymphocyte-activation molecule (SLAM), acting as an inhibitor by blocking SHP-2 recruitment. It can also bind to related surface molecules on activated T, B, and NK cells, modulating signal transduction pathways.
Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 (Duncan disease), a rare immunodeficiency characterized by extreme susceptibility to Epstein-Barr virus infection, severe mononucleosis, and malignant lymphoma. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.