Thermo Fisher Scientific SH2D1A Polyclonal Antibody
Rabbit polyclonal antibody against human SH2D1A protein. Validated for ICC/IF applications. Supplied as a liquid, unconjugated form with 0.05 mg/mL concentration. Suitable for studying T and B cell signaling pathways. For research use only.
- 카탈로그번호
- PA5145022
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SH2D1A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3091844 |
Immunogen Information
- Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 3–29)
- Recombinant protein control fragment: Product #RP-110143
- Immunogen sequence: AVAVYHGKIS RETGEKLLLA TGLDGSY
- Antigen sequence identity: Mouse 96%; Rat 93%
Target Information
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. The protein contains an SH2 domain and a short tail, and associates with the signaling lymphocyte-activation molecule (SLAM), acting as an inhibitor by blocking SHP-2 recruitment. It can also bind to related surface molecules on activated T, B, and NK cells, modulating signal transduction pathways.
Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 (Duncan disease), a rare immunodeficiency characterized by extreme susceptibility to Epstein-Barr virus infection, severe mononucleosis, and malignant lymphoma. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.