Thermo Fisher Scientific LYL1 Polyclonal Antibody
Rabbit polyclonal antibody against human LYL1 protein. Validated for ICC/IF applications. Supplied as liquid, unconjugated form with 0.05 mg/mL concentration. Suitable for research use in leukemia and hematopoiesis studies.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 95–150). Recombinant protein control fragment: Product # RP-109949 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092135 |
Product Specific Information
- Immunogen sequence:
TAPPTLALHY HPHPFLNSVY IGPAGPFSIF PSSRLKRRPS HCELDLAEGH QPQKVA - Antigen sequence identity: Mouse 91%; Rat 93%
Target Information
Lyl-1, TAL1, and TAL2 belong to a family of basic helix-loop-helix (bHLH) proteins implicated in T cell acute leukemia. TAL1 (SCL) is a serine phosphoprotein and transcription factor regulating embryonic hematopoiesis. TAL2 is involved in T cell acute lymphoblastic leukemia through chromosomal translocation with T cell receptor β chain genes. Lyl-1 (lymphoblastic leukemia-derived sequence 1) is a nuclear protein forming heterodimeric complexes with E2α proteins, exhibiting unique DNA-binding properties in hematolymphoid cells. Lyl-1 is associated with chromosomal aberrations causing T cell acute lymphoblastic leukemia (T-ALL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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