Thermo Fisher Scientific JMY Polyclonal Antibody
Rabbit polyclonal antibody recognizing human JMY protein. Validated for WB and IP applications. Useful for studying p53 signaling and actin dynamics. Supplied as liquid, 0.2 mg/mL, stored at 4°C. For research use only.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific JMY Polyclonal Antibody
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 800 and 850 of human junction mediating and regulatory protein (JMY). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
JMY acts as both a nuclear p53/TP53 cofactor and a cytoplasmic regulator of actin dynamics depending on conditions.
In the nucleus, it functions as a cofactor that enhances the p53/TP53 response via interaction with p300/EP300, increasing p53/TP53-dependent transcription and apoptosis. This suggests an important role in p53/TP53 stress responses such as DNA damage.
In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and unbranched actin filaments, activating the Arp2/3 complex to induce branched actin filament networks. It can also catalyze actin polymerization in the absence of Arp2/3, forming unbranched filaments.
JMY contributes to cell motility by controlling actin dynamics and may facilitate rapid formation of branched actin networks by nucleating new mother filaments and subsequently activating Arp2/3 to branch off these filaments.
Its dual functions as a p53/TP53 cofactor and actin activator are regulated by subcellular localization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.