Thermo Fisher Scientific JMY Polyclonal Antibody
Thermo Fisher Scientific의 JMY Polyclonal Antibody는 인간 JMY 단백질을 표적으로 하는 토끼 유래 IgG 항체입니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C에서 보관합니다.
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Thermo Fisher Scientific JMY Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human junction mediating and regulatory protein (JMY) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
JMY acts both as a nuclear p53/TP53 cofactor and a cytoplasmic regulator of actin dynamics depending on conditions.
In the nucleus, it increases p53/TP53-dependent transcription and apoptosis through interaction with p300/EP300, playing a key role in stress responses such as DNA damage.
In the cytoplasm, JMY serves as a nucleation-promoting factor for both branched and unbranched actin filaments, activating the Arp2/3 complex and catalyzing actin polymerization.
It contributes to cell motility by controlling actin dynamics and promotes rapid formation of branched actin networks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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