Thermo Fisher Scientific PTPN2 Polyclonal Antibody
PTPN2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC, IP 등 다양한 응용에 적합. Human과 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS 기반 용액 형태로 4°C 단기, -20°C 장기 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 1:100–1:600 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human TCPTP (proprietary sequence) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.18 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736694 |
Product Specific Information
- Positive Control: 293T, A431, HeLa, HepG2
- Predicted Reactivity: Rat (94%), Chicken (81%), Bovine (93%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins.
This enzyme has two C-terminal splice variants with distinct subcellular localizations:
- The 45 kDa isoform is nuclear in resting cells but redistributes to the cytosol upon stimulation with growth factors or cellular stress.
- The 48 kDa isoform is localized in the endoplasmic reticulum and has different physiological substrates.
TC-PTP is expressed in many cell types, particularly in hematopoietic cells. Knockout mice lacking TC-PTP exhibit erythropoietic and lymphopoietic deficits, indicating its critical role in bone marrow maturation.
It dephosphorylates various phosphoproteins such as p52 Shc and receptors for EGF, insulin, and growth hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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