Thermo Fisher Scientific CD38 Monoclonal Antibody (HB7), PE, eBioscience

Applications

Flow Cytometry (Flow)

• Tested Dilution: 5 µL (0.06 µg)/test
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Product Specifications

Additional Formats

• eFluor 450
• FITC
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Red 710
• NovaFluor Red 725
• NovaFluor Yellow 660
• NovaFluor Yellow 755
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 600
• Super Bright 702
• Request custom conjugation

Product Specific Information

The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein.
CD38 catalyzes NAD into nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR), which act as secondary messengers.
CD38 expression varies during B cell development and is also found in T cells, NK cells, monocytes, and other tissues.
It is used for leukemia phenotyping and HIV-1 progression monitoring.
The CD34⁺CD38⁻ hematopoietic stem cell population defines the most pluripotent cells.
CD38 has also been observed in the nucleus, potentially regulating calcium levels.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested for human peripheral blood cells.
Use 5 µL (0.06 µg) per test in 100 µL final volume.
Cell number per test: 10⁵–10⁸ cells (empirically determined).
Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein involved in activation, proliferation, and differentiation of lymphocytes, and mediates apoptosis of progenitor cells.
It functions as a multi-catalytic ectoenzyme (ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD⁺ glycohydrolase) or as a surface receptor.
Antibodies to CD38 are used in lymphoma and leukemia subtyping, plasma cell detection (e.g., myelomas), and as markers for activated B and T cells.
CD38 participates in cell adhesion, signal transduction, and calcium signaling, and is expressed in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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