Thermo Fisher Scientific TMEM38A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Immunohistochemistry (IHC)

• Tested Dilution: 20 µg/mL

Product Specifications

Product Specific Information

• Suggested positive control: Rat skeletal muscle tissue lysate
• PA5-20858 can be used with blocking peptide PEP-0972.

Target Information

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes.
TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues.
Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca²⁺ handling, weakened Ca²⁺ release, and reduced K⁺ permeability.
These findings indicate that TRIC cation channels likely act as counter-ion channels functioning in synchronization with Ca²⁺ release from intracellular stores.
TMEM38A and TMEM38B can also interact with junctophilin proteins to support efficient ryanodine receptor-mediated Ca²⁺ release in muscle cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.