Thermo Fisher Scientific CD7 Polyclonal Antibody
CD7 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 시료에 반응합니다. Western blot, IHC, IP 등 다양한 응용에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 190 to 240 of human CD7 molecule |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.
The N-terminal amino acids (1–107) are highly homologous to Ig kappa-L chains, while the C-terminal extracellular domain is proline-rich and may form a stalk structure from which the Ig domain projects.
CD7 is expressed on most immature and mature T-lymphocytes and T cell leukemia cells. It is also found on natural killer cells, a small subset of normal B cells, and malignant B cells.
Cross-linking of surface CD7 modulates T cell and NK cell activity, influencing calcium fluxes, adhesion molecule expression, cytokine secretion, and proliferation.
CD7 directly associates with phosphoinositol 3-kinase, and ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
Expression of CD7 serves as an important marker in leukemia diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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