Thermo Fisher Scientific CD7 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.
The N-terminal amino acids (1–107) are highly homologous to Ig kappa-L chains, while the C-terminal extracellular domain is proline-rich and may form a stalk structure from which the Ig domain projects.

CD7 is expressed on most immature and mature T-lymphocytes and T cell leukemia cells. It is also found on natural killer cells, a small subset of normal B cells, and malignant B cells.
Cross-linking of surface CD7 modulates T cell and NK cell activity, influencing calcium fluxes, adhesion molecule expression, cytokine secretion, and proliferation.
CD7 directly associates with phosphoinositol 3-kinase, and ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
Expression of CD7 serves as an important marker in leukemia diagnostics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.