Thermo Fisher Scientific IL-17F Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute with 0.1 mL of distilled water.
Prior to reconstitution, store at 4°C. After reconstitution, store undiluted at -20°C, avoiding freeze/thaw cycles.

Rabbit anti-Human interleukin-17F antibody recognizes human IL-17F (interleukin-17F), a disulfide-linked homodimer consisting of two 133 amino acid chains. IL-17F belongs to the IL-17 gene family and shares the highest sequence homology with IL-17A.

Target Information

IL-17F (Interleukin 17F, CTLA-8) is a cytokine belonging to the IL-17 family, produced by inflammatory cells such as activated T cells, mast cells, and basophils. It is involved in allergic airway inflammation and induces several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils.

IL-17F may be secreted as a homodimer or heterodimer with IL-17A, acting via the IL-17R receptor to recruit monocytes and neutrophils by increasing chemokine production. It also stimulates pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and IL-8, and is implicated in chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.

TGF-β and IL-23 are required for differentiation and maintenance of Th17 (IL-17-producing) cells, which further induce other pro-inflammatory cytokines. IL-17F, one of six IL-17 family members (A–F), is highly expressed by activated effector memory T cells and has been reported to inhibit angiogenesis and induce endothelial IL-2, TGF-β, and MCP-1 production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.