Thermo Fisher Scientific ACVR2A Polyclonal Antibody
Human ACVR2A 단백질을 인식하는 Goat Polyclonal Antibody. Western blot, IHC, Neutralization에 적합. 항원 친화 크로마토그래피로 정제되었으며, 보존제 무첨가. Activin 신호전달 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL |
| Neutralization (Neu) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Sf21-derived recombinant human Activin RIIA (Ser25–Asp82) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609085 |
Product Specific Information
- In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human Activin RIIB is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor serine/threonine kinases.
ACVR2A participates in activin and myostatin signaling pathways (Aliases: ACVR2, ACTRII).
These receptors are transmembrane proteins with extracellular cysteine-rich ligand-binding domains, a transmembrane region, and a cytoplasmic domain with serine/threonine kinase activity.
Type I receptors are essential for signaling, while Type II receptors bind ligands and promote Type I receptor expression.
Upon ligand binding, Type I and Type II receptors form a stable complex, leading to phosphorylation of Type I receptors by Type II receptors.
Type II receptors are constitutively active kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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