Thermo Fisher Scientific IL-22 Polyclonal Antibody
IL-22 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ELISA에 사용 가능. 인간 spleen 또는 tonsil 조직 양성 대조로 권장. IL-22 신호전달 및 염증 반응 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| ELISA | 1:100,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues C(40)RLDKSNFQQPYITNRTFMLAKEASLAD(67) of human IL22 precursor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2248942 |
Product Specific Information
Positive control of human spleen or tonsil tissue is suggested.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and a member of the IFN-IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
Produced mainly by activated T cells and NK cells, IL-22 gene is located on chromosome 12q and structurally related to IL-10.
IL-22 acts via the heterodimeric receptor complex IL-22R1/IL-10R2, initiating JAK-STAT signaling.
A soluble IL-22 receptor (IL-22BP) antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells (skin, digestive, respiratory systems, hepatocytes, keratinocytes).
It functions as an effector cytokine of Th17 lineage, co-expressed with IL-17A and IL-17F, regulating innate immunity genes of the skin.
IL-22 induces acute phase reactants, antimicrobial proteins, and keratinocyte mobility, and is upregulated during chronic inflammation.
It is critical for host defense against extracellular pathogens and promotes wound healing.
IL-22 mediates IL-23-induced acanthosis and dermal inflammation via STAT3 activation.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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