Thermo Fisher Scientific IL-22 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive control of human spleen or tonsil tissue is suggested.

Target Information

IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and a member of the IFN-IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
Produced mainly by activated T cells and NK cells, IL-22 gene is located on chromosome 12q and structurally related to IL-10.
IL-22 acts via the heterodimeric receptor complex IL-22R1/IL-10R2, initiating JAK-STAT signaling.
A soluble IL-22 receptor (IL-22BP) antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells (skin, digestive, respiratory systems, hepatocytes, keratinocytes).
It functions as an effector cytokine of Th17 lineage, co-expressed with IL-17A and IL-17F, regulating innate immunity genes of the skin.
IL-22 induces acute phase reactants, antimicrobial proteins, and keratinocyte mobility, and is upregulated during chronic inflammation.
It is critical for host defense against extracellular pathogens and promotes wound healing.
IL-22 mediates IL-23-induced acanthosis and dermal inflammation via STAT3 activation.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.