Thermo Fisher Scientific IL-22 Polyclonal Antibody
Human 및 Mouse 반응성 IL-22 폴리클로날 항체로, IHC 및 ELISA에 적합합니다. Goat에서 생산된 IgG 형태이며, 합성 Human IL-22 C-말단 펩타이드를 면역원으로 사용합니다. 액상 형태로 1 mg/mL 농도, 친화 크로마토그래피로 정제되어 연구용으로 제공됩니다.
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Thermo Fisher Scientific IL-22 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:300 |
| ELISA | 1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of Human IL22 C terminal amino acids 148–177 (LKDTVKKLGESGEIKAIGELDLLFMSLRNA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M potassium phosphate with 0.14M NaCl, 0.1% BSA |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2295881 |
Product Specific Information
Recommended positive controls: Human spleen and tonsil.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine in the IFN-IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
Produced mainly by activated T cells and NK cells, IL-22 gene is located on chromosome 12q and structurally related to IL-10.
It acts through the heterodimeric receptor complex IL-22R1 and IL-10R2, triggering JAK-STAT signaling.
A soluble receptor, IL-22BP, antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells such as skin, digestive, respiratory cells, hepatocytes, and keratinocytes.
It is an effector cytokine of Th17 lineage, co-expressed with IL-17A and IL-17F, regulating innate immunity genes.
Functions include induction of acute phase reactants, antimicrobial proteins, and enhancing keratinocyte mobility.
Highly expressed during chronic inflammation, IL-22 activates intracellular kinases and transcription factors, crucial for host defense and wound healing.
It mediates IL-23-induced acanthosis and dermal inflammation via STAT3 activation.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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