Thermo Fisher Scientific IL-22 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500

Product Specifications

Product Specific Information

• Recommended positive controls: Mouse spleen

Target Information

IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and member of the IFN-IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
It is mainly produced by activated T cells and NK cells. In humans, the IL-22 gene is located on chromosome 12q and is structurally related to IL-10.
IL-22 acts via the heterodimeric receptor complex IL-22R1 and IL-10R2, which also interact with IL-20, IL-24, IL-10, IL-27, IL-28, and IL-29.
Binding of IL-22 to its receptor induces JAK-STAT signaling. A soluble receptor, IL-22BP, antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells such as skin, digestive, respiratory cells, hepatocytes, and keratinocytes, functioning as an effector cytokine of the Th17 lineage.
It regulates innate immunity genes of the skin, induces acute phase reactants and antimicrobial proteins, and promotes keratinocyte mobility and wound healing.
IL-22 is upregulated in activated T cells and mediates IL-23-induced dermal inflammation via STAT3 activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.