Thermo Fisher Scientific IL-22 Polyclonal Antibody
Thermo Fisher Scientific IL-22 Polyclonal Antibody는 마우스 IL-22 단백질을 인식하는 Rabbit IgG 항체로, IHC(P)에서 1:500 희석 비율로 검증되었습니다. 비결합형 액상 형태이며, 4°C 단기 및 -20°C 장기 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues K(40)LEVSNFQQPYIVNRTFMLAKEASLAD(67) of mouse IL22 precursor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2124355 |
Product Specific Information
- Recommended positive controls: Mouse spleen
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and member of the IFN-IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
It is mainly produced by activated T cells and NK cells. In humans, the IL-22 gene is located on chromosome 12q and is structurally related to IL-10.
IL-22 acts via the heterodimeric receptor complex IL-22R1 and IL-10R2, which also interact with IL-20, IL-24, IL-10, IL-27, IL-28, and IL-29.
Binding of IL-22 to its receptor induces JAK-STAT signaling. A soluble receptor, IL-22BP, antagonizes IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells such as skin, digestive, respiratory cells, hepatocytes, and keratinocytes, functioning as an effector cytokine of the Th17 lineage.
It regulates innate immunity genes of the skin, induces acute phase reactants and antimicrobial proteins, and promotes keratinocyte mobility and wound healing.
IL-22 is upregulated in activated T cells and mediates IL-23-induced dermal inflammation via STAT3 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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