Thermo Fisher Scientific PUMA delta/gamma Polyclonal Antibody
PUMA 단백질을 인식하는 Thermo Fisher Scientific의 goat polyclonal 항체로, Western blot에 최적화되어 있습니다. p53 경로 관련 세포사멸 연구에 적합하며, 고순도 액상 형태로 제공됩니다. 인체 시료 반응성이 확인된 연구용 시약입니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PUMA delta/gamma Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 0.1–0.3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (DGGRPQRTVR) corresponding to the internal amino acids of BBC3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982799 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
PUMA (p53 upregulated modulator of apoptosis) is a pro-apoptotic Bcl-2 family member along with Bax and Noxa, which are transcriptional targets of p53.
The PUMA gene encodes two BH3 domain-containing proteins, PUMA-a and PUMA-b.
PUMA proteins bind Bcl-2, localize to mitochondria, and induce cytochrome c release and apoptosis in response to p53 activation.
Antisense inhibition of PUMA expression reduces the apoptotic response to p53, suggesting PUMA plays a key role in mediating p53-induced cell death via the cytochrome c/Apaf-1-dependent pathway.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.