Thermo Fisher Scientific PGRP-S Polyclonal Antibody
Human PGRP-S 단백질을 인식하는 Goat Polyclonal 항체로, Western blot 및 IHC(P) 분석에 적합. 합성 펩타이드 면역원으로 제작되었으며, 0.5 mg/mL 농도의 액상 형태. TBS buffer(pH 7.3) 기반으로 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–6 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (PGNQLYHLIQN) corresponding to the C-terminus amino acids of PGLYRP1 (aa 179–190) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983370 |
Product Specific Information
- This antibody is predicted to react with canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 4,000.
Target Information
The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever.
A family of proteins called peptidoglycan recognition proteins (PGRPs) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria.
PGN is an essential cell wall component of virtually all bacteria and is an excellent target for recognition by the eukaryotic innate immune system.
The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules.
PGRP-L is primarily expressed in the liver, while PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria, functioning as a neutrophil antibacterial protein.
PGRP-S is also highly expressed in human bone marrow, suggesting additional, yet unidentified roles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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