Thermo Fisher Scientific RRP8 Polyclonal Antibody
RRP8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 사용 가능. 1 mg/mL 액상 형태로 제공되며, 4°C에서 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 to 50 of Human Ribosomal RNA Processing 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates rDNA silencing in response to intracellular energy status by recruiting histone-modifying enzymes. Upon glucose starvation, an increased NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation and subsequent dimethylation at Lys-9 (H3K9me2) by SUV39H1, forming silent chromatin in the rDNA locus. Within this complex, RRP8 binds to H3K9me2 and likely functions as a methyltransferase, though its substrates remain unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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