Thermo Fisher Scientific ATF1 Monoclonal Antibody (OTI5D10), TrueMAB
ATF1 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western Blot 및 IHC(P) 실험에 적합. 인간 시료 반응성, 친화 크로마토그래피 정제, 고순도 액상 형태. 연구용으로 세포 성장 및 생존 관련 유전자 발현 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D10 |
| Immunogen | Full length human recombinant protein of human ATF1 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes related to growth, survival, and other cellular activities.
This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase, and cyclin-dependent kinase 3 (cdk-3).
Phosphorylation enhances transactivation and transcriptional activities, promoting cell transformation.
Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma.
This gene has a pseudogene on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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