Thermo Fisher Scientific TOPORS Polyclonal Antibody
TOPORS 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. 인간과 생쥐 시료에 반응하며, E3 유비퀴틴-프로틴 리가아제 연구에 활용됩니다. Affinity chromatography로 정제된 액상 형태의 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TOPORS (Accession Q9NS56), corresponding to amino acid residues D850–N900 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850304 |
Product Specific Information
Antibody detects endogenous levels of total TOPORS.
Target Information
TOPORS functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. It is a probable tumor suppressor involved in cell growth, proliferation, and apoptosis by regulating p53/TP53 stability through ubiquitin-dependent degradation. It may also regulate chromatin modification through sumoylation of chromatin-associated proteins and participate in DNA damage-induced cell death through IKBKE sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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