Thermo Fisher Scientific Human IL-32 Synthetic Peptide

Thermo Fisher Scientific Human IL-32 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the carboxy terminus of human IL-32.
PEP-0334 can be used as a blocking peptide with polyclonal antibody PA5-20221.

Target Information

Interleukin-32 (IL-32) was initially identified as a transcript (NK4) selectively expressed in lymphocytes and NK cells, with expression increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and renamed IL-32.
IL-32 is unique in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms.
Treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-α, IL-8, and MIP-2. It is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFN-γ. Therefore, IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.