Thermo Fisher Scientific Human LSD1 Synthetic Peptide
인간 LSD1의 중심부 16개 아미노산 서열로 구성된 합성 펩타이드. PA5-20227 항체의 차단 펩타이드로 사용 가능. 히스톤 탈메틸화 효소 연구에 적합하며, PBS(pH 7.2) 내 0.1% BSA와 0.02% sodium azide 포함. -20°C에서 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the center of human LSD1.
PEP-0340 can be used as a blocking peptide with polyclonal antibody PA5-20227.
Target Information
LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a marker for epigenetic transcriptional activation, thereby acting as a corepressor.
LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. It is a component of several histone deacetylase complexes and silences genes by functioning as a histone demethylase.
It acts by oxidizing the substrate via FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylated Lys-4 of histone H3 and may play a role in repression of neuronal genes.
Alone, it cannot demethylate H3 Lys-4 on nucleosomes and requires RCOR1/CoREST for activity. It may also demethylate Lys-9 of histone H3, leading to derepression of androgen receptor target genes.
Mutations in this gene can result in cleft palate, psychomotor retardation, and distinctive facial features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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