Thermo Fisher Scientific RGR Polyclonal Antibody
Human RGR 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 등에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 1 mg/mL 농도. -20°C 보관, 연구용 전용 시약.
- 카탈로그번호
- PA5100993
- 판매단위
- pk
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Thermo Fisher Scientific RGR Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | View publication |
| Immunomicroscopy (IM) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RGR (Accession P47804), corresponding to amino acid residues S130–M180 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850474 |
Product Specific Information
Antibody detects endogenous levels of total RGR.
Target Information
This gene encodes a putative retinal G-protein coupled receptor and is a member of the opsin subfamily of the 7-transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain.
The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells.
The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, such as the retinal pigment epithelium and Mueller cells.
This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP). Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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