Thermo Fisher Scientific ALAS1 Polyclonal Antibody
ALAS1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간 및 마우스 시료에서 반응. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific ALAS1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ALAS1 (Accession P13196), corresponding to amino acid residues C398–G448 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850475 |
Product Specific Information
Antibody detects endogenous levels of total ALAS1.
Target Information
ALAS1 (Aminolevulinate Synthase 1) is a nuclear-encoded mitochondrial matrix enzyme that catalyzes the condensation of glycine with succinyl-CoA to form δ-aminolevulinate, CO₂, and CoA.
It regulates the first and rate-limiting step of the heme biosynthetic pathway. As one of two ALAS isoforms, ALAS1 is a pyridoxal-5'-phosphate-dependent housekeeping enzyme expressed ubiquitously, providing heme for cytochromes and other hemoproteins.
ALAS1 in liver is negatively regulated by heme and transcriptionally stimulated by cAMP and respiratory uncoupling. Phorbol esters and insulin repress ALAS1 gene expression.
ALAS1 may be involved in reciprocal regulation of heme biosynthesis and the circadian clock, suggesting a potential therapeutic target for circadian disorders.
Downregulation of ALAS1 expression in acute liver failure is associated with altered heme metabolism and impaired liver function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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