Thermo Fisher Scientific Factor VIII Polyclonal Antibody, Biotin
Human Factor VIII에 특이적인 Biotin 결합 폴리클로날 항체로 Western Blot, ELISA, Immunoprecipitation에 적합. Rabbit IgG 기반으로 고순도 정제. 안정적 액상 형태로 -20°C에서 보관. 연구용으로 혈액응고 관련 단백질 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1:50–1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 200–250 on human Coagulation Factor VIII protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation. Factor VIII acts as a cofactor for factor IXa, which, in the presence of Ca²⁺ and phospholipids, converts factor X to the activated form Xa.
Two alternatively spliced transcripts are produced:
- Transcript variant 1 encodes isoform a, a large glycoprotein circulating in plasma and forming a noncovalent complex with von Willebrand factor.
- Transcript variant 2 encodes isoform b, a smaller protein consisting mainly of the phospholipid-binding domain essential for coagulant activity.
Defects in this gene result in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송 정보
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