Thermo Fisher Scientific ZNF638 Polyclonal Antibody
Human ZNF638 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZNF638. Recombinant protein control fragment (Product #RP-95983). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2650252 |
Product Specific Information
Immunogen sequence:
GLLKPTSARS GLAESSSKFK PTQSSLTRGG SGRISALQGK LSKLDYRDIT KQSQETEARP SIMKRDDSNN KTLAEQNTKN PK
Highest antigen sequence identity to the following orthologs:
- Mouse: 76%
- Rat: 76%
Target Information
Zinc-finger proteins contain DNA-binding domains and have diverse functions related to transcriptional activation or repression.
NP220 (Nuclear protein 220), also known as Zinc finger protein 638 (ZNF638) or Cutaneous T-cell lymphoma-associated antigen se33-1, is a 1978 amino acid protein containing one matrin-type zinc finger and two RRM (RNA recognition motif) domains, suggesting a role in transcriptional regulation.
NP220 binds to double-stranded DNA fragments by recognizing clusters of cytidines, interacts with FHL-2, and may be phosphorylated by ATM or ATR upon DNA damage.
It exists as five isoforms due to alternative splicing events. Isoform five of NP220 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL) cases, including mycosis fungoides and Sezary syndrome patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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