Thermo Fisher Scientific DACH1 Polyclonal Antibody
DACH1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. Western blot 및 IHC(P) 실험에 적합하며, 다양한 종에 반응. 0.5 mg/mL 농도의 액상 형태로 제공되며 Protein A로 정제됨. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 5–7 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Chicken, Horse, Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Amino acids 474–501 of human DACH1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540983 |
Target Information
Transcription factor involved in regulation of organogenesis. Acts as a regulator of SIX1, SIX6, and possibly SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also involves association with CREBBP. Functions as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds chromatin DNA via its DACHbox-N domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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