Thermo Fisher Scientific CD20 (MS4A1) Monoclonal Antibody (OTI10A5), Biotin, TrueMAB
인간 CD20 단백질을 인식하는 Biotin 결합 단클론 항체로, ELISA 및 Luminex 분석에 적합합니다. HEK293T 세포에서 발현된 full-length 인간 MS4A1 항원을 면역원으로 사용하였으며, 고순도의 Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
ELISA (ELISA)
- Tested Dilution: 1:250–1:1,000
Luminex (LUM)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10A5 |
| Immunogen | Full length human recombinant protein of human MS4A1 produced in HEK293T cell |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa, depending on phosphorylation. It is expressed on mature and most malignant B cells, a subpopulation of T lymphocytes, and follicular dendritic cells. CD20 regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation. It is associated with lipid rafts, and its association varies with extracellular triggers and BCR aggregation. CD20 remains on the cell surface after receptor ligation and is a key target for antibody-mediated B-cell depletion, as it is highly expressed on most B-cell malignancies and is not internalized or shed after treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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