Thermo Fisher Scientific Nucleophosmin Recombinant Mouse Monoclonal Antibody (rNPM1, 1901)
Thermo Fisher의 Nucleophosmin rNPM1, 1901 항체는 인간 NPM1 단백질을 표적으로 하는 재조합 마우스 모노클로날 항체입니다. Western blot, IHC, Flow cytometry에 적합하며, 고순도 Protein A/G 정제 및 PBS buffer로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Nucleophosmin Recombinant Mouse Monoclonal Antibody (rNPM1, 1901)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rNPM1, 1901 |
| Immunogen | Recombinant human NPM1 protein fragment (aa185–287) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C or −80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- For formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, then cool at room temperature for 20 min.
Target Information
NPM1 (Nucleophosmin 1, also known as B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in:
- Ribosome assembly and transport
- Cytoplasmic/nuclear trafficking
- Regulation of DNA polymerase α activity
- Centrosome duplication
- Regulation of p53
NPM1 shuttles between the nucleus, cytoplasm, and nucleolus, chaperoning core histones. It binds nucleic acids, prevents protein aggregation, protects enzymes during thermal denaturation, and assists protein renaturation. NPM1 is associated with centrosome duplication and acts as a substrate of CDK2/cyclin E. It interacts with tumor-associated translocations forming fusion proteins (NPM-ALK, NPM-RAR, NPM-MLF1) and may facilitate oncogenic conversion. Additionally, NPM1 sequesters tumor suppressor RF in the nucleolus, protecting it until required. Dysfunction of NPM1 is linked to diseases such as acute myeloid leukemia and lymphomatoid papulosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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