Thermo Fisher Scientific IKZF3 Recombinant Rabbit Monoclonal Antibody (4U7F9)
Thermo Fisher Scientific의 IKZF3(Aiolos) 단클론 항체로, 인간·마우스·랫트 반응성. WB, IHC, ICC, ELISA, IP 등에 사용 가능. HEK293 발현 시스템 기반, 고순도 친화 크로마토그래피 정제. B세포 발달 및 분화 연구용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:800 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 200 µg–400 µg extracts |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4U7F9 |
| Immunogen | Recombinant fusion protein containing amino acids 400–509 of human IKZF3 (Q9UKT9) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912030 |
Product Specific Information
- Positive test controls include: Raji, Mouse spleen, Mouse thymus, Rat lung.
- Immunogen sequence:
IYQQNHMVLS RARNGMPLLK EVPRSYELLK PPPICPRDSV KVINKEGEVM DVYRCDHCRV LFLDYVMFTI HMGCHGFRDP FECNMCGYRS HDRYEFSSHI ARGEHRALLK
Target Information
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos, and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development.
This gene product is a transcription factor important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos requires the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers.
At least six alternative transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일 예시: MA5-42889_Aiolos_IKZF3_Q9UKT9-1_Rabbit.svg, MA5-42889_Aiolos_IKZF3_Q9UKT9-1_Rabbit_PDP.jpeg)
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