Thermo Fisher Scientific WNK1 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 WNK1 단백질에 대한 Rabbit Polyclonal Antibody. IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되어 95% 이상 순도. 전해질 항상성 및 세포 신호 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 20–68 of Human WNK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803009 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
WNK1 serine/threonine kinase is a member of the WNK subfamily. It may regulate blood pressure by controlling sodium and chloride ion transport. Mutations in this gene are associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK1 plays a key role in electrolyte homeostasis, cell signaling, survival, and proliferation. It acts as both an activator and inhibitor of sodium- and potassium-coupled chloride cotransporters, respectively, and activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK1 localizes to the distal nephron, a kidney segment involved in salt, potassium, and pH homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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