Thermo Fisher Scientific CD276 Monoclonal Antibody (1A6)
CD276(B7-H3) 단백질을 인식하는 마우스 단클론 항체. Western blot과 ELISA에 사용 가능. 인간 및 생쥐 시료 반응성. Affinity chromatography로 정제된 액상형 항체로, 보존제 무첨가. -20°C에서 보관.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A6 |
| Immunogen | CD276 (AAH62581.1, 237–358 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ITPQRSPTGA VEVQVPEDPV VALVGTDATL RCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FTEGRDQGSA YANRTALFPD LLAQGNASLR LQRVRVADEG SFTCFVSIRD FGSAAVSLQV AA
Target Information
CD276 is a member of the B7 family of co-stimulatory molecules, also known as B7-H3.
It is a type I transmembrane protein that:
- Induces proliferation of CD4⁺ and CD8⁺ T cells
- Enhances generation of cytotoxic T cells
- Stimulates interferon gamma production
Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also found in peripheral tissues such as heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing.
It has potential therapeutic relevance in regulating immune responses to cancer, particularly alongside anti-angiogenic therapies.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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