Thermo Fisher Scientific UBE2C Recombinant Rabbit Monoclonal Antibody (ARC1166)
Thermo Fisher의 UBE2C 재조합 토끼 단클론 항체(ARC1166)는 인간 UBE2C 단백질을 특이적으로 인식합니다. WB, ICC/IF, ELISA에 사용 가능하며, 고순도의 액상 항체로 세포주기 연구 및 암 관련 단백질 분석에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1166 |
| Immunogen | Synthetic peptide corresponding to amino acids 70–150 of human UBE2C (UniProt ID: O00762) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.83 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849574 |
Product Specific Information
Immunogen sequence:
AGTVYEDLRY KLSLEFPSGY PYNAPTVKFL TPCYHPNVDT QGNICLDILK EKWSALYDVR TILLSIQSLL GEPNIDSPLN T
Target Information
The UBE2C gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is essential for the destruction of mitotic cyclins and cell cycle progression, and may be involved in cancer progression. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, it catalyzes Lys-11- and Lys-48-linked polyubiquitination. UBE2C acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis by initiating Lys-11-linked polyubiquitin chains on APC/C substrates, leading to their degradation by the proteasome and promoting mitotic exit.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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