Thermo Fisher Scientific OLFM1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

The Olfactomedin family comprises a diverse group of secreted glycoproteins, including OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin, and myocilin. These proteins are implicated in the development of the nervous system.

Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse embryos (E8–10), and later in brain tissue and the zone of polarizing activity in the limb. Overexpression of OLFM1 causes excess neural crest emigrations and prolonged neural crest production. OLFM2 participates in regulating the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.