Thermo Fisher Scientific APP Monoclonal Antibody (OTI6F11), TrueMAB
APP 단백질을 인식하는 OTI6F11 클론의 마우스 단일클론 항체. Western blot, IHC, ICC/IF에 사용 가능. 고순도의 친화 크로마토그래피 정제 제품으로, PBS/BSA/glycerol 완충액에 보관. 알츠하이머 연구 등 신경 관련 단백질 분석에 적합.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6F11 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK23T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms resulting from alternative splicing. Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, the primary component of senile plaques—one of the major histopathologic features of Alzheimer’s disease. Abnormal regulation and processing of APP are also implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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