Thermo Fisher Scientific LSD1 Polyclonal Antibody
LSD1 단백질을 표적하는 Thermo Fisher Scientific의 염소 유래 Polyclonal 항체. Western blot 및 Peptide ELISA에 적합하며, Human 시료 반응성. 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific LSD1 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 0.5–1.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-KHWDQDDDFEFTGSH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933022 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a tag for epigenetic transcriptional activation, thereby acting as a corepressor. It contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1 is part of several histone deacetylase complexes and silences genes by functioning as a histone demethylase. It oxidizes substrates via FAD to form imine intermediates that are hydrolyzed. LSD1 demethylates both mono- and tri-methylated Lys-4 of histone H3 and may repress neuronal genes. It requires RCOR1/CoREST for nucleosomal activity and may also demethylate Lys-9 of histone H3, leading to derepression of androgen receptor target genes. Mutations in this gene can cause cleft palate, psychomotor retardation, and distinctive facial features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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